Selected Research Articles
Josh Tycko, Mike V. Van, Aradhana, Nicole DelRosso, David Yao, Xiaoshu Xu, Connor Ludwig, Kaitlyn K. Spees, Kathy Liu, Gaelen T. Hess, Mingxin Gu, Aditya Mukund, Peter H. Suzuki, Roarke A. Kamber, Lei S. Qi, Lacramioara Bintu, M. Bassik
bioRxiv, 2023
Large-scale mapping and mutagenesis of human transcriptional effector domains
Nicole DelRosso, Josh Tycko, Peter H. Suzuki, Cecelia Andrews, Aradhana, Aditya Mukund, Ivan Liongson, Connor Ludwig, Kaitlyn K. Spees, P. Fordyce, M. Bassik, Lacramioara Bintu
Nature, 2023
Matthew Durrant*, Alison Fanton*, Josh Tycko*, Michaela Hinks, Sita Chandrasekaran, Nicholas T Perry, Julia M. Schaepe, Peter P. Du, Peter Lotfy, Michael Bassik, Lacramioara Bintu, Ami Bhatt, Patrick Hsu
Nature Biotechnology, 2022
High-Throughput Discovery and Characterization of Human Transcriptional Effectors
Josh Tycko, Nicole DelRosso, Gaelen T. Hess, Aradhana, A. Banerjee, Aditya Mukund, Mike V. Van, Braeden K. Ego, David Yao, Kaitlyn K. Spees, Peter H. Suzuki, G. Marinov, A. Kundaje, M. Bassik#, Lacramioara Bintu#
Cell, 2020
Mitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elements
Josh Tycko*, M. Wainberg*, G. Marinov*, Oana Ursu, Gaelen T. Hess, Braeden K. Ego, Aradhana, Amy Li, Alisa N Truong, Alexandro E. Trevino, Kaitlyn K. Spees, David Yao, Irene M. Kaplow, P. Greenside, D. Morgens, D. Phanstiel, M. Snyder, Lacramioara Bintu, W. Greenleaf, A. Kundaje, M. Bassik
Nature Communications, 2019
Josh Tycko, Luis A. Barrera, Nicholas C. Huston, Ari E. Friedland, Xuebing Wu, J. Gootenberg, O. Abudayyeh, V. Myer, Christopher J. Wilson, P. Hsu
Nature Communications, 2018
Reviews
The sound of silence: Transgene silencing in mammalian cell engineering.
A Cabera*, HI Edelstein*, F Glykofrydis*, KS Love*, S Palacios*, J Tycko*, M Zhang*, S Lensch, CE Shields, M Livingston, R Weiss, H Zhao, K Haynes, L Morsut, YY Chen, AS Khalil, W Wong, J Collins, S Rosser, K Polizzi, M Elowitz, M Fussenegger, IB Hilton, JN Leonard, L Bintu, KE Galloway, TL Deans
Cell Systems, 2022
Gene drives for schistosomiasis transmission control
T. Maier, Nicolas J. Wheeler, E. Namigai, Josh Tycko, R. Grewelle, Y. Woldeamanuel, Katharina Klohe, J. Perez-Saez, S. Sokolow, G. D. De Leo, T. Yoshino, M. Zamanian, J. Reinhard-Rupp
PLoS Neglected Tropical Diseases, 2019
Methods and Applications of CRISPR-Mediated Base Editing in Eukaryotic Genomes.
Gaelen T. Hess*, Josh Tycko*, David Yao*, M. Bassik
Molecular Cell, 2017
Josh Tycko*, Mike V. Van*, Michael B. Elowitz, Lacramioara Bintu
Current Opinion in Biomedical Engineering, vol. 4, 2017 Oct 30, pp. 174-193
Methods for Optimizing CRISPR-Cas9 Genome Editing Specificity.
Josh Tycko, Vic Myer, Patrick Hsu
Molecules and Cells, 2016
Lessons Learned from the Clinical Development and Market Authorization of Glybera
Laura M. Bryant*, Devin M. Christopher*, April R. Giles*, Christian Hinderer*, Jesse L. Rodriguez*, Jenessa B. Smith*, Elizabeth A. Traxler*, Josh Tycko*, Adam P. Wojno*, James M. Wilson
Human gene therapy. Clinical development, vol. 24(2), 2013 Apr 12, pp. 55-64
Additional Research Articles
CasKAS: direct profiling of genome-wide dCas9 and Cas9 specificity using ssDNA mapping
G. Marinov, Samuel H. Kim, S. Bagdatli, Soon Il Higashino, Alexandro E. Trevino, Josh Tycko, Tong Wu, Lacramioara Bintu, M. Bassik, Chuan He, A. Kundaje, W.J. Greenleaf
Genome Biology, 2023
Aditya Mukund, Josh Tycko, Sage J. Allen, S. A. Robinson, Cecelia Andrews, Connor Ludwig, Kaitlyn K. Spees, M. Bassik, Lacramioara Bintu
bioRxiv, 2022
High-Throughput Discovery and Characterization of Viral Transcriptional Effectors in Human Cells
Connor H. Ludwig, A. Thurm, D. Morgens, Kevin J. Yang, Josh Tycko, M. Bassik, B. Glaunsinger, Lacramioara Bintu
bioRxiv, 2022
Modeling the efficacy of CRISPR gene drive for snail immunity on schistosomiasis control
R. Grewelle, J. Perez-Saez, Josh Tycko, E. Namigai, Chloe Rickards, G. D. De Leo
PLoS Neglected Tropical Diseases, 2022
Josh Tycko, V. Adam, M. Crosariol, J. Ohlstein, Julio C. Sanmiguel, A. Tretiakova, Soumitra Roy, S. Worgall, James M. Wilson, M. Limberis
Human gene therapy, 2021
A genome-wide genetic screen uncovers novel determinants of human pigmentation
V. Bajpai, T. Swigut, Jaaved Mohammed, Josh Tycko, S. Naqvi, M. Arreola, Tayne C. Kim, Neha Arora, J. Pritchard, M. Bassik, J. Wysocka
bioRxiv, 2021
Identification of Guide-Intrinsic Determinants of Cas9 Specificity
Nicholas C. Huston, Josh Tycko, Eric L Tillotson, Christopher J. Wilson, V. Myer, H. Jayaram, Barrett E Steinberg
The CRISPR Journal, 2019
Maxwell R. Mumbach, Ansuman T. Satpathy, E. Boyle, Chao Dai, Benjamin G. Gowen, S. Cho, M. Nguyen, Adam J. Rubin, Jeffrey M Granja, Katelynn R. Kazane, Yuning Wei, Trieu Nguyen, P. Greenside, M. Corces, Josh Tycko, Dimitre R. Simeonov, Nabeela Suliman, Rui Li, Jin Xu, Ryan A. Flynn, A. Kundaje, P. Khavari, A. Marson, J. Corn, T. Quertermous, W. Greenleaf, Howard Y. Chang
Nature Genetics, 2017
Toolbox for Exploring Modular Gene Regulation in Synthetic Biology Training.
Michael S. Magaraci, Jessica G Bermudez, Deeksha Yogish, D. H. Pak, Viktor Mollov, Josh Tycko, D. Issadore, Sevile G. Mannickarottu, B. Chow
ACS synthetic biology, 2016