I develop systematic experimental technologies that enable progress toward a quantitative understanding of gene expression while keeping the door open for unexpected biological discoveries. Recently, we developed a new approach, HT-recruit, to measure how domains from all proteins in the human nucleus can affect gene expression when recruited to a target gene. We discovered transcriptional effector domains in 600 human proteins and shed new light on the evolution of major transcription factor families, like KRAB and Hox.
My long-term goal is to apply this knowledge to develop safe gene therapies that cure diseases. I have employed a variety of high-throughput methods to better measure, model, and mitigate CRISPR gene editing off-target activity, working in both academia and at a biotech startup.
I completed my Ph.D. in the labs of Michael Bassik and Lacra Bintu with support from the NIH F99/K00 Fellowship. At Stanford, I was a teaching assistant for a course on the science and bioethics of CRISPR, was an instructor for a hands-on cell engineering lab, and mentor to our amazing iGEM team. As a BioFutures Fellow and co-leader of The Genetics Advocacy Committee, I collaborated with fellow trainees to critically analyze and improve graduate STEM training.
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